Biomarkers of Cancer Stem Cells

Biomarkers refers to substance or process which indicates the presence of cancer in the body, and are particularly associated with genetic mutations or epigenetic alterations, which determine whether individuals are susceptible to particular types of cancers. Some of the potentially predictive cancer biomarkers include mutations on genes such as KRAS, p53, EGFR, erbB2 for colorectal, esophageal, liver, and pancreatic cancer, discussed in Oncology Meetings. Mutations of genes such as BRCA1and BRCA2 are for breast and ovarian cancer. abnormal  methylation of  tumour suppressor genes  like  p16, CDKN2B, and p14ARF are mostly  for brain cancer. hypermethylation of MYOD1, CDH1, and CDH13 are for cervical cancer and finally hyper methylation of p16, p14, and RB1, for oral cancer. Therefore these kinds of biomarkers can be assayed in non-invasively collected biofluids like blood or serum.

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